diff --git a/.changeset/poor-insects-complain.md b/.changeset/poor-insects-complain.md
new file mode 100644
index 0000000000..455c2a3241
--- /dev/null
+++ b/.changeset/poor-insects-complain.md
@@ -0,0 +1,6 @@
+---
+"@medusajs/admin-ui": patch
+"@medusajs/admin": patch
+---
+
+fix(admin-ui): Omit PriceList prices from variant update
diff --git a/packages/admin-ui/ui/src/components/organisms/product-variants-section/edit-variant-modal.tsx b/packages/admin-ui/ui/src/components/organisms/product-variants-section/edit-variant-modal.tsx
index 915b5c469c..c938abeeb4 100644
--- a/packages/admin-ui/ui/src/components/organisms/product-variants-section/edit-variant-modal.tsx
+++ b/packages/admin-ui/ui/src/components/organisms/product-variants-section/edit-variant-modal.tsx
@@ -197,12 +197,15 @@ export const getEditVariantDefaultValues = (
       length: variant.length,
     },
     prices: {
-      prices: variant.prices.map((price) => ({
-        id: price.id,
-        amount: price.amount,
-        currency_code: price.currency_code,
-        region_id: price.region_id,
-      })),
+      prices: variant.prices
+        // Price list prices cannot be saved from the edit variant modal
+        .filter((price) => !price.price_list_id)
+        .map((price) => ({
+          id: price.id,
+          amount: price.amount,
+          currency_code: price.currency_code,
+          region_id: price.region_id,
+        })),
     },
     options,
     metadata: getMetadataFormValues(variant.metadata),